Treatment Extension of Pegylated Interferon Alpha and Ribavirin Does Not Improve SVR in Patients with Genotypes 2/3 without Rapid Virological Response (OPTEX Trial): A Prospective, Randomized, Two-Arm, Multicentre Phase IV Clinical Trial

Although sofosbuvir has been approved for patients with genotypes 2/3 (G2/3), many parts of the world still consider pegylated Interferon alpha (P) and ribavirin (R) as standard of care for G2/3. Patients with rapid virological response (RVR) show response rates >80%. However, SVR (sustained viro...

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Veröffentlicht in:PLoS One
Hauptverfasser: Heidrich, Benjamin, Cordes, Hans-Jörg, Klinker, Hartwig, Möller, Bernd, Naumann, Uwe, Rössle, Martin, Kraus, Michael R., Böker, Klaus H., Roggel, Christoph, Schuchmann, Marcus, Stoehr, Albrecht, Trein, Andreas, Hardtke, Svenja, Gonnermann, Andrea, Koch, Armin, Wedemeyer, Heiner, Manns, Michael P., Cornberg, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461366/
https://ncbi.nlm.nih.gov/pubmed/26057627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128069
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