HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in colorectal cancer. Therefore, here we explored a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Wenjing, Shi, Xinpeng, Peng, Ying, Wu, Meiyan, Zhang, Pei, Xie, Ruyi, Wu, Yao, Yan, Qingqing, Liu, Side, Wang, Jide
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461314/
https://ncbi.nlm.nih.gov/pubmed/26057751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129603
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