A Mouse-Adapted Enterovirus 71 Strain Causes Neurological Disease in Mice after Oral Infection

A mouse-adapted enterovirus 71 (EV71) strain with increased virulence in mice, MP4, was generated after four serial passages of the parental EV71 strain 4643 in mice. Strain MP4 exhibited a larger plaque size, grew more rapidly, and was more cytotoxic in vitro than strain 4643. Although strains 4643...

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Detalhes bibliográficos
Main Authors: Wang, Ya-Fang, Chou, Chun-Ting, Lei, Huan-Yao, Liu, Ching-Chuan, Wang, Shih-Min, Yan, Jing-Jou, Su, Ih-Jen, Wang, Jen-Reng, Yeh, Trai-Ming, Chen, Shun-Hua, Yu, Chun-Keung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC446098/
https://ncbi.nlm.nih.gov/pubmed/15254164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.7916-7924.2004
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