Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which pathogenesis and death of motor neurons are triggered by non-cell-autonomous mechanisms. We showed earlier that exposing primary rat spinal cord cultures to conditioned media derived from primary mouse astrocyte condit...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Rojas, Fabiola, Gonzalez, David, Cortes, Nicole, Ampuero, Estibaliz, Hernández, Diego E., Fritz, Elsa, Abarzua, Sebastián, Martinez, Alexis, Elorza, Alvaro A., Alvarez, Alejandra, Court, Felipe, van Zundert, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460879/
https://ncbi.nlm.nih.gov/pubmed/26106294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00203
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