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Using homology relations within a database markedly boosts protein sequence similarity search

Inference of homology from protein sequences provides an essential tool for analyzing protein structure, function, and evolution. Current sequence-based homology search methods are still unable to detect many similarities evident from protein spatial structures. In computer science a search engine c...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tong, Jing, Sadreyev, Ruslan I., Pei, Jimin, Kinch, Lisa N., Grishin, Nick V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460465/
https://ncbi.nlm.nih.gov/pubmed/26038555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424324112
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