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Bootstrap Restricted Likelihood Ratio Test for the Detection of Rare Variants

In this paper the detection of rare variants association with continuous phenotypes of interest is investigated via the likelihood-ratio based variance component test under the framework of linear mixed models. The hypothesis testing is challenging and nonstandard, since under the null the variance...

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Detalles Bibliográficos
Publicado en:Curr Genomics
Autores principales: Zeng, Ping, Wang, Ting
Formato: Artigo
Lenguaje:Inglês
Publicado: Bentham Science Publishers 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460223/
https://ncbi.nlm.nih.gov/pubmed/26069459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1389202916666150304234203
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