Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis

BACKGROUND: Oral infection of C57BL/6J mice with the protozoan parasite Toxoplasma gondii leads to a lethal inflammatory ileitis. PRINCIPAL FINDINGS: Mice lacking the purinergic receptor P2X7R are acutely susceptible to toxoplasmic ileitis, losing significantly more weight than C57BL/6J mice and exh...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Miller, Catherine M., Zakrzewski, Alana M., Robinson, Dionne P., Fuller, Stephen J., Walker, Robert A., Ikin, Rowan J., Bao, Shisan J., Grigg, Michael E., Wiley, James S., Smith, Nicholas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460092/
https://ncbi.nlm.nih.gov/pubmed/26053862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129048
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