Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates

BACKGROUND: Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflammatory effects prior to further clinical...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zalenskaya, Irina A., Joseph, Theresa, Bavarva, Jasmin, Yousefieh, Nazita, Jackson, Suzanne S., Fashemi, Titilayo, Yamamoto, Hidemi S., Settlage, Robert, Fichorova, Raina N., Doncel, Gustavo F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459878/
https://ncbi.nlm.nih.gov/pubmed/26052926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128557
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