Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

Angiopoietin-1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. We hypothesized that systemic therapy with Vasculotide (VT)—a purported Ang1 mimetic, Tie2 agonist—can reduce the extravasation of...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Wu, Florence TH, Lee, Christina R, Bogdanovic, Elena, Prodeus, Aaron, Gariépy, Jean, Kerbel, Robert S
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459817/
https://ncbi.nlm.nih.gov/pubmed/25851538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404193
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