Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems

Single-stranded DNA oligonucleotides (ssODNs) can direct the repair of a single base mutation in human genes. While the regulation of this gene editing reaction has been partially elucidated, the low frequency with which repair occurs has hampered development toward clinical application. In this wor...

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Bibliographic Details
Published in:PLoS One
Main Authors: Bialk, Pawel, Rivera-Torres, Natalia, Strouse, Bryan, Kmiec, Eric B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459703/
https://ncbi.nlm.nih.gov/pubmed/26053390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129308
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