Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the de...

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Vydáno v:AIDS Res Hum Retroviruses
Hlavní autoři: Saravanan, Shanmugam, Gomathi, Selvamurthi, Kausalya, Bagavathi, Boobalan, Jayaseelan, Murugavel, Kailapuri G, Balakrishnan, Pachamuthu, Mothi, Sarvode N., Solomon, Sunil S., Kumarasamy, Nagalingeswaran, Selvamuthu, Poongulali, Solomon, Suniti, Smith, Davey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Sequence Note
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458742/
https://ncbi.nlm.nih.gov/pubmed/25839730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0023
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