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CDKN2A/p16 loss implicates CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans

Dermatofibrosarcoma protuberans (DFSP) is an aggressive PDGFB-dependent cutaneous sarcoma characterized by infiltrative growth and frequent local recurrences. Some DFSP progress to a higher-grade fibrosarcomatous form, with rapid growth and increased risk of metastasis. Imatinib provides clinical be...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Eilers, Grant, Czaplinski, Jeffrey T., Mayeda, Mark, Bahri, Nacef, Tao, Derrick, Zhu, Meijun, Hornick, Jason L., Lindeman, Neal I., Sicinska, Ewa, Wagner, Andrew J., Fletcher, Jonathan A., Mariño-Enriquez, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458458/
https://ncbi.nlm.nih.gov/pubmed/25852058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0793
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