Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mouse and Human Dependent on BLK Expression Levels

Polymorphisms in the BLK gene have been associated with autoimmune diseases, including systemic lupus erythematosus (SLE), with risk correlating with reduced expression of BLK. How reduced expression of BLK causes autoimmunity is unknown. Using Blk(+/+), Blk(+/−), and Blk(−/−) mice, we show that age...

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Publicat a:J Immunol
Autors principals: Wu, Ying-Yu, Georg, Ina, Díaz-Barreiro, Alejandro, Varela, Nieves, Lauwerys, Bernard, Kumar, Ramesh, Bagavant, Harini, Castillo-Martín, Mireia, Salem, Fadi El, Marañón, Concepción, Alarcón-Riquelme, Marta E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458437/
https://ncbi.nlm.nih.gov/pubmed/25972485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402736
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