Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mouse and Human Dependent on BLK Expression Levels

Polymorphisms in the BLK gene have been associated with autoimmune diseases, including systemic lupus erythematosus (SLE), with risk correlating with reduced expression of BLK. How reduced expression of BLK causes autoimmunity is unknown. Using Blk(+/+), Blk(+/−), and Blk(−/−) mice, we show that age...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Wu, Ying-Yu, Georg, Ina, Díaz-Barreiro, Alejandro, Varela, Nieves, Lauwerys, Bernard, Kumar, Ramesh, Bagavant, Harini, Castillo-Martín, Mireia, Salem, Fadi El, Marañón, Concepción, Alarcón-Riquelme, Marta E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458437/
https://ncbi.nlm.nih.gov/pubmed/25972485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402736
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