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Quinolyl analogues of norlobelane: Novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2
We have previously shown that quinolyl moieties are attractive structural replacements for the phenyl groups in lobelane. These quinolyl analogues had improved water-solubility over lobelane and retained the potent vesicular monoamine transporter-2 (VMAT-2) inhibitory properties of the parent compou...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4457633/ https://ncbi.nlm.nih.gov/pubmed/25991431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.105 |
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