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Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain

In a rat model of neuroinflammation induced with a low-dose infusion lipopolysaccharide (5.0 ng/hr, LPS), we reported that brain arachidonic acid (ARA, 20:4 n-6), but not docosahexaenoic acid (DHA, 22:6n-3), metabolism is increased compared to control rats. To further characterize the impact LPS has...

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Detalhes bibliográficos
Publicado no:Inflamm Cell Signal
Main Authors: Houdek, Heidi M., Larson, Jordan, Watt, John A., Rosenberger, Thad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457330/
https://ncbi.nlm.nih.gov/pubmed/26052539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14800/ics.47
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