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Toxicity of weekly oral topotecan in relation to dosage for gynecologic malignancies: a phase I study

The aim of this study was to determine the dose of weekly oral topotecan that allows safe administration and to evaluate the pharmacokinetics of this dose in patients with recurrent gynecologic malignancies. The first cohort of patients received oral topotecan 6 mg/week administered orally on days 1...

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Detalhes bibliográficos
Publicado no:Anticancer Drugs
Main Authors: von Gruenigen, Vivian E., Frasure, Heidi E., Smith, Deborah A., Fusco, Nancy L., Eaton, Susan M., DeBernardo, Robert L., Heugeland, Anne M., Waggoner, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457288/
https://ncbi.nlm.nih.gov/pubmed/22555194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0b013e32835396d4
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