A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors

Higher Notch signaling is known to be associated with hematological and solid cancers. We developed a potential immunotherapeutic monoclonal antibody (MAb) specific for the Negative Regulatory Region of Notch1 (NRR). The MAb604.107 exhibited higher affinity for the “Gain-of-function” mutants of Notc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sharma, Ankur, Gadkari, Rupali A, Ramakanth, Satthenapalli V, Padmanabhan, Krishnanand, Madhumathi, Davanam S, Devi, Lakshmi, Appaji, Lingappa, Aster, Jon C, Rangarajan, Annapoorni, Dighe, Rajan R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457015/
https://ncbi.nlm.nih.gov/pubmed/26046801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11012
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