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Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS

Determining the distribution of a drug and its metabolites within tissue is a key facet of evaluating drug candidates. Drug distribution can have a significant implication in appraising drug efficacy and potential toxicity. The specificity and sensitivity of mass spectrometry imaging (MSI) make it a...

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Foilsithe in:Int J Mass Spectrom
Main Authors: Barry, Jeremy A., Groseclose, M. Reid, Robichaud, Guillaume, Castellino, Stephen, Muddiman, David C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456684/
https://ncbi.nlm.nih.gov/pubmed/26056514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2014.05.012
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