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Functional Genomic Screening Approaches in Mechanistic Toxicology and Potential Future Applications of CRISPR-Cas9

Characterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment. Chemical toxicants act by many different mechanisms, however, and the genes involved in adverse outcome pathways (AOPs) and AOP networks are not yet chara...

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Detalhes bibliográficos
Publicado no:Mutat Res Rev Mutat Res
Main Authors: Shen, Hua, McHale, Cliona M., Smith, Martyn T, Zhang, Luoping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456615/
https://ncbi.nlm.nih.gov/pubmed/26041264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrrev.2015.01.002
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