Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology

The fusion of monocyte/macrophage lineage cells into fully active, multinucleated, bone resorbing osteoclasts is a complex cell biological phenomenon that utilizes specialized proteins. OC-STAMP, a multi-pass transmembrane protein, has been shown to be required for pre-osteoclast fusion and for opti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Witwicka, Hanna, Hwang, Sung-Yong, Reyes-Gutierrez, Pablo, Jia, Hong, Odgren, Paul E., Donahue, Leah Rae, Birnbaum, Mark J., Odgren, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456411/
https://ncbi.nlm.nih.gov/pubmed/26042409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128275
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