The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBM), harbor highly recurrent TERT promoter muta...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Bell, Robert J.A., Rube, H. Tomas, Kreig, Alex, Mancini, Andrew, Fouse, Shaun D., Nagarajan, Raman P., Choi, Serah, Hong, Chibo, He, Daniel, Pekmezci, Melike, Wiencke, John K., Wrensch, Margaret R., Chang, Susan M., Walsh, Kyle M., Myong, Sua, Song, Jun S., Costello, Joseph F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456397/
https://ncbi.nlm.nih.gov/pubmed/25977370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab0015
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