Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity

AIMS: Methadone is characterized by wide intersubject variability regarding the dose needed to obtain full therapeutic response. We assessed the influence of sociodemographic, ethnic, clinical, metabolic and genotypic variables on methadone maintenance dose requirement in opioid-dependent responder...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Mouly, Stéphane, Bloch, Vanessa, Peoc'h, Katell, Houze, Pascal, Labat, Laurence, Ksouda, Kamilia, Simoneau, Guy, Declèves, Xavier, Bergmann, Jean Francois, Scherrmann, Jean-Michel, Laplanche, Jean-Louis, Lepine, Jean-Pierre, Vorspan, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456129/
https://ncbi.nlm.nih.gov/pubmed/25556837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12576
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