Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by l-DOPA?(†)

Inflammatory mechanisms are proposed to play a role in l-DOPA-induced dyskinesia. Cyclooxygenase-2 (COX2) contributes to inflammation pathways in the periphery and is constitutively expressed in the central nervous system. Considering that inhibition of nitric oxide (NO) formation attenuates l-DOPA-...

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Bibliographic Details
Published in:Philos Trans R Soc Lond B Biol Sci
Main Authors: Bortolanza, Mariza, Padovan-Neto, Fernando E., Cavalcanti-Kiwiatkoski, Roberta, dos Santos-Pereira, Maurício, Mitkovski, Miso, Raisman-Vozari, Rita, Del-Bel, Elaine
Format: Artigo
Language:Inglês
Published: The Royal Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455759/
https://ncbi.nlm.nih.gov/pubmed/26009769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0190
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