Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase (sGC), which produces the second messeng...

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Vydáno v:Nat Commun
Hlavní autoři: Hoffmann, Linda S., Etzrodt, Jennifer, Willkomm, Lena, Sanyal, Abhishek, Scheja, Ludger, Fischer, Alexander W.C., Stasch, Johannes-Peter, Bloch, Wilhelm, Friebe, Andreas, Heeren, Joerg, Pfeifer, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455111/
https://ncbi.nlm.nih.gov/pubmed/26011238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8235
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