Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

Beclin 1, a protein essential for autophagy, regulates autophagy by interacting with Vps34 and other cofactors to form the Beclin 1 complex. Modifications of Beclin 1 may lead to the induction, inhibition or fine-tuning of the autophagic response under a variety of conditions. Here we show that Becl...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Sun, Ting, Li, Xuan, Zhang, Peng, Chen, Wen-Dan, Zhang, Hai-liang, Li, Dan-Dan, Deng, Rong, Qian, Xiao-Jun, Jiao, Lin, Ji, Jiao, Li, Yun-Tian, Wu, Rui-Yan, Yu, Yan, Feng, Gong-Kan, Zhu, Xiao-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455096/
https://ncbi.nlm.nih.gov/pubmed/26008601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8215
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