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New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

Natural peptides show high degrees of specificity in their biological action. However, their therapeutical profile is severely limited by their conformational freedom and metabolic instability. Stapled peptides constitute a solution to these problems and access to these structures lies on a limited...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Mendive-Tapia, Lorena, Preciado, Sara, García, Jesús, Ramón, Rosario, Kielland, Nicola, Albericio, Fernando, Lavilla, Rodolfo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Pub. Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455059/
https://ncbi.nlm.nih.gov/pubmed/25994485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8160
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