Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors

The G9a histone methyltransferase inhibitor BIX01294 was examined for its ability to expand the cardiac capacity of bone marrow cells. Inhibition of G9a histone methyltransferase by gene specific knockdown or BIX01294 treatment was sufficient to induce expression of precardiac markers Mesp1 and brac...

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Publicado en:Stem Cells Int
Autores principales: Yang, Jinpu, Kaur, Keerat, Ong, Li Lin, Eisenberg, Carol A., Eisenberg, Leonard M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454756/
https://ncbi.nlm.nih.gov/pubmed/26089912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/270428
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