Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for presentation to T-lymphocytes. Antigen internalization and processing rely on the early dynein-dependent transport of BCR–antigen microclusters to the syn...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Reversat, Anne, Yuseff, Maria-Isabel, Lankar, Danielle, Malbec, Odile, Obino, Dorian, Maurin, Mathieu, Penmatcha, Naga Venkata Gayathri, Amoroso, Alejandro, Sengmanivong, Lucie, Gundersen, Gregg G., Mellman, Ira, Darchen, François, Desnos, Claire, Pierobon, Paolo, Lennon-Duménil, Ana-Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454175/
https://ncbi.nlm.nih.gov/pubmed/25631815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-09-1373
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