Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy

BACKGROUND: Autophagy allows recycling of cellular components and may facilitate cell survival after chemotherapy. Pantoprazole inhibits proton pumps and is reported to inhibit autophagy. Here we evaluate the effects of pantoprazole to modify cytotoxicity of the anticancer drug docetaxel, and underl...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Tan, Q, Joshua, A M, Saggar, J K, Yu, M, Wang, M, Kanga, N, Zhang, J Y, Chen, X, Wouters, B G, Tannock, I F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453951/
https://ncbi.nlm.nih.gov/pubmed/25647012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.17
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