A phase I dose-escalation study of eribulin and S-1 for metastatic breast cancer

BACKGROUND: We evaluated the safety, maximum-tolerated dose (MTD), pharmacokinetics, recommended dose for phase II (P2RD), and preliminary anticancer activity of a combination eribulin and S-1 therapeutic in metastatic breast cancer patients pretreated with anthracycline and taxane. METHOD: Patients...

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Dettagli Bibliografici
Pubblicato in:Br J Cancer
Autori principali: Sakiyama, T, Tsurutani, J, Iwasa, T, Kawakami, H, Nonagase, Y, Yoshida, T, Tanaka, K, Fujisaka, Y, Kurata, T, Komoike, Y, Nishio, K, Nakagawa, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Clinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453950/
https://ncbi.nlm.nih.gov/pubmed/25654665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.10
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