Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

BACKGROUND: Chemotherapy response in ovarian cancer patients is frequently compromised by drug resistance, possibly due to altered drug metabolism. Platinum drugs are metabolised by glutathione S-transferase P1 (GSTP1), which is abundantly, but variably expressed in ovarian tumours. We have created...

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Detalles Bibliográficos
Publicado en:Br J Cancer
Autores principales: Sawers, L, Ferguson, M J, Ihrig, B R, Young, H C, Chakravarty, P, Wolf, C R, Smith, G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453841/
https://ncbi.nlm.nih.gov/pubmed/25010864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.386
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