Effects of preset sequential administrations of sunitinib and everolimus on tumour differentiation in Caki-1 renal cell carcinoma

BACKGROUND: Sunitinib (VEGFR/PDGFR inhibitor) and everolimus (mTOR inhibitor) are both approved for advanced renal cell carcinoma (RCC) as first-line and second-line therapy, respectively. In the clinics, sunitinib treatment is limited by the emergence of acquired resistance, leading to a switch to...

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Publicat a:Br J Cancer
Autors principals: Santos, C D, Tijeras-Raballand, A, Serova, M, Sebbagh, S, Slimane, K, Faivre, S, de Gramont, A, Raymond, E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453618/
https://ncbi.nlm.nih.gov/pubmed/25422908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.578
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