USA300 and USA500 Clonal Lineages of Staphylococcus aureus Do Not Produce a Capsular Polysaccharide Due to Conserved Mutations in the cap5 Locus

The surface capsular polysaccharide (CP) is a virulence factor that has been used as an antigen in several successful vaccines against bacterial pathogens. A vaccine has not yet been licensed against Staphylococcus aureus, although two multicomponent vaccines that contain CP antigens are in clinical...

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Bibliographic Details
Published in:mBio
Main Authors: Boyle-Vavra, Susan, Li, Xue, Alam, Md Tauqeer, Read, Timothy D., Sieth, Julia, Cywes-Bentley, Colette, Dobbins, Ginette, David, Michael Z., Kumar, Neha, Eells, Samantha J., Miller, Loren G., Boxrud, David J., Chambers, Henry F., Lynfield, Ruth, Lee, Jean C., Daum, Robert S.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453534/
https://ncbi.nlm.nih.gov/pubmed/25852165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02585-14
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