Targeted Knockout of the Rickettsia rickettsii OmpA Surface Antigen Does Not Diminish Virulence in a Mammalian Model System

Strains of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever (RMSF), differ dramatically in virulence despite >99% genetic homology. Spotted fever group (SFG) rickettsiae produce two immunodominant outer membrane proteins, rickettsial OmpA (rOmpA) and rOmpB, which are con...

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Bibliografiset tiedot
Julkaisussa:mBio
Päätekijät: Noriea, Nicholas F., Clark, Tina R., Hackstadt, Ted
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Microbiology 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453529/
https://ncbi.nlm.nih.gov/pubmed/25827414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00323-15
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