B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P

BACKGROUND: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SS...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Inoue, A, Okamoto, K, Fujino, Y, Nakagawa, T, Muguruma, N, Sannomiya, K, Mitsui, Y, Takaoka, T, Kitamura, S, Miyamoto, H, Okahisa, T, Fujimori, T, Imoto, I, Takayama, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Genetics & Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453443/
https://ncbi.nlm.nih.gov/pubmed/25314065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.545
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