Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells

INTRODUCTION: Acquired tamoxifen resistance remains the major obstacle to breast cancer endocrine therapy. β1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estrogen receptor recognized as an initiator of tamoxifen resistance. Here, we inves...

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Publicado no:Breast Cancer Res
Main Authors: Yuan, Jie, Liu, Manran, Yang, Li, Tu, Gang, Zhu, Qing, Chen, Maoshan, Cheng, Hong, Luo, Haojun, Fu, Weijie, Li, Zhenhua, Yang, Guanglun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453053/
https://ncbi.nlm.nih.gov/pubmed/25990368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0579-y
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