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Carboxypeptidase B2 Deficiency Reveals Opposite Effects of Complement C3a and C5a in a Murine Polymicrobial Sepsis Model
BACKGROUND AND OBJECTIVES: Carboxypeptidase B2 (CPB2) is a basic carboxypeptidase with fibrin and complement C3a and C5a as physiological substrates. We hypothesized that in polymicrobial sepsis, CPB2-deficient mice would have sustained C5a activity, leading to disease exacerbation. METHODS: Polymic...
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| Publicado no: | J Thromb Haemost |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452409/ https://ncbi.nlm.nih.gov/pubmed/25851247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12956 |
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