The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer

The transcription factor c-Myc plays critical roles in cancer development and progression through regulating expression of targeted genes. Lactate dehydrogenase A (LDHA), which catalyzes the conversion of l-lactate to pyruvate in the final step of anaerobic glycolysis, is frequently upregulated in p...

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Vydáno v:Med Oncol
Hlavní autoři: He, Tian-Lin, Zhang, Yi-Jie, Jiang, Hui, Li, Xiao-hui, Zhu, Hai, Zheng, Kai-Lian
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2015
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452209/
https://ncbi.nlm.nih.gov/pubmed/26021472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12032-015-0633-8
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