Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis

Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key features of systemic sclerosis (SSc). ET-1 receptors (ET(A) and ET(B)) are expressed on endothelial cells, smooth muscle cells, and fibroblasts, but their presence on immune cells has not been deeply in...

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Dettagli Bibliografici
Pubblicato in:J Immunol Res
Autori principali: Elisa, Tinazzi, Antonio, Puccetti, Giuseppe, Patuzzo, Alessandro, Barbieri, Giuseppe, Argentino, Federico, Confente, Marzia, Dolcino, Ruggero, Beri, Giacomo, Marchi, Andrea, Ottria, Daniela, Righetti, Mariaelisa, Rampudda, Claudio, Lunardi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451773/
https://ncbi.nlm.nih.gov/pubmed/26090478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/147616
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