Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days

AIM: To quantify in vivo the biodistribution of poly(lactic-co-glycolic) acid (PLGA) and PLGA/chitosan nanoparticles (PLGA/Chi NPs) and assess if the positive charge of chitosan significantly enhances nanoparticle absorption in the GI tract. MATERIAL & METHODS: PLGA and PLGA/Chi NPs covalently l...

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Dettagli Bibliografici
Pubblicato in:Ther Deliv
Autori principali: Navarro, Sara M, Darensbourg, Caleb, Cross, Linda, Stout, Rhett, Coulon, Diana, Astete, Carlos E, Morgan, Timothy, Sabliov, Cristina M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451574/
https://ncbi.nlm.nih.gov/pubmed/25491670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.14.79
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