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Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal-copper, high-fructose diet in male rats

High-fructose feeding impairs copper status and leads to low copper availability, which is a novel mechanism in obesity-related fatty liver. Copper deficiency-associated hepatic iron overload likely plays an important role in fructose-induced liver injury. Excess iron in the liver is distributed thr...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Song, Ming, Schuschke, Dale A., Zhou, Zhanxiang, Zhong, Wei, Zhang, Jiayuan, Zhang, Xiang, Wang, Yuhua, McClain, Craig J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451322/
https://ncbi.nlm.nih.gov/pubmed/25813056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00285.2014
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