An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 deficiency was associated with increased fibrin deposition and persistence, and thicker clots, followed by increased col...

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Published in:J Exp Med
Main Authors: Doni, Andrea, Musso, Tiziana, Morone, Diego, Bastone, Antonio, Zambelli, Vanessa, Sironi, Marina, Castagnoli, Carlotta, Cambieri, Irene, Stravalaci, Matteo, Pasqualini, Fabio, Laface, Ilaria, Valentino, Sonia, Tartari, Silvia, Ponzetta, Andrea, Maina, Virginia, Barbieri, Silvia S., Tremoli, Elena, Catapano, Alberico L., Norata, Giuseppe D., Bottazzi, Barbara, Garlanda, Cecilia, Mantovani, Alberto
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451130/
https://ncbi.nlm.nih.gov/pubmed/25964372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141268
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