Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

NF-κB is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-κB pathway in a discovery and validation CLL cohort totaling 315 cases. The...

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Publicat a:J Exp Med
Autors principals: Mansouri, Larry, Sutton, Lesley-Ann, Ljungström, Viktor, Bondza, Sina, Arngården, Linda, Bhoi, Sujata, Larsson, Jimmy, Cortese, Diego, Kalushkova, Antonia, Plevova, Karla, Young, Emma, Gunnarsson, Rebeqa, Falk-Sörqvist, Elin, Lönn, Peter, Muggen, Alice F., Yan, Xiao-Jie, Sander, Birgitta, Enblad, Gunilla, Smedby, Karin E., Juliusson, Gunnar, Belessi, Chrysoula, Rung, Johan, Chiorazzi, Nicholas, Strefford, Jonathan C., Langerak, Anton W., Pospisilova, Sarka, Davi, Frederic, Hellström, Mats, Jernberg-Wiklund, Helena, Ghia, Paolo, Söderberg, Ola, Stamatopoulos, Kostas, Nilsson, Mats, Rosenquist, Richard
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451125/
https://ncbi.nlm.nih.gov/pubmed/25987724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142009
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