Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes

In metazoans, transition from fetal to adult heart is accompanied by a switch in energy metabolism-glycolysis to fatty acid oxidation. The molecular factors regulating this metabolic switch remain largely unexplored. We first demonstrate that the molecular signatures in 1-year (y) matured human embr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kuppusamy, Kavitha T., Jones, Daniel C., Sperber, Henrik, Madan, Anup, Fischer, Karin A., Rodriguez, Marita L., Pabon, Lil, Zhu, Wei-Zhong, Tulloch, Nathaniel L., Yang, Xiulan, Sniadecki, Nathan J., Laflamme, Michael A., Ruzzo, Walter L., Murry, Charles E., Ruohola-Baker, Hannele
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450404/
https://ncbi.nlm.nih.gov/pubmed/25964336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424042112
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