Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis: The IDEA Randomized Clinical Trial

IMPORTANCE: Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. OBJECTIVE: To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clin...

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Bibliographic Details
Published in:JAMA
Main Authors: Messier, Stephen P., Mihalko, Shannon L., Legault, Claudine, Miller, Gary D., Nicklas, Barbara J., DeVita, Paul, Beavers, Daniel P., Hunter, David J., Lyles, Mary F., Eckstein, Felix, Williamson, Jeff D., Carr, J. Jeffery, Guermazi, Ali, Loeser, Richard F.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450354/
https://ncbi.nlm.nih.gov/pubmed/24065013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2013.277669
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