The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

Intestinal epithelial cell (IEC) death is typical of inflammatory bowel disease (IBD). We investigated: i) whether IEC–released necrotic cell products (proinflammatory mediators) amplify mucosal inflammation, ii) the capacity of necrotic cell lysates from HT29 cells or human IECs to induce human int...

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Detaylı Bibliyografya
Yayımlandı:Am J Pathol
Asıl Yazarlar: Scarpa, Melania, Kessler, Sean, Sadler, Tammy, West, Gail, Homer, Craig, McDonald, Christine, de la Motte, Carol, Fiocchi, Claudio, Stylianou, Eleni
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2015
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450321/
https://ncbi.nlm.nih.gov/pubmed/25864926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.02.018
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