Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity

Large deletions in mitochondrial DNA (mtDNA) may be involved in the pathogenesis of mitochondrial disease. In this study, we investigated the relationship between a 4,977-bp deletion in the mitochondrial genome (ΔmtDNA(4977)) and the severity of clinical symptoms in patients with mitochondrial disea...

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Vydáno v:PLoS One
Hlavní autoři: Zhang, Yanchun, Ma, Yinan, Bu, Dingfang, Liu, Hui, Xia, Changyu, Zhang, Ying, Zhu, Sainan, Pan, Hong, Pei, Pei, Zheng, Xuefei, Wang, Songtao, Xu, Yufeng, Qi, Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449107/
https://ncbi.nlm.nih.gov/pubmed/26024530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128624
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