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Deletion of a 4977-bp Fragment in the Mitochondrial Genome Is Associated with Mitochondrial Disease Severity

Large deletions in mitochondrial DNA (mtDNA) may be involved in the pathogenesis of mitochondrial disease. In this study, we investigated the relationship between a 4,977-bp deletion in the mitochondrial genome (ΔmtDNA(4977)) and the severity of clinical symptoms in patients with mitochondrial disea...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Yanchun, Ma, Yinan, Bu, Dingfang, Liu, Hui, Xia, Changyu, Zhang, Ying, Zhu, Sainan, Pan, Hong, Pei, Pei, Zheng, Xuefei, Wang, Songtao, Xu, Yufeng, Qi, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449107/
https://ncbi.nlm.nih.gov/pubmed/26024530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128624
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