Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis

A safer and more effective anti-Tuberculosis vaccine is still an urgent need. We probed the effects of monosodium urate crystals (MSU) on innate immunity to improve the Bacille Calmette-Guerin (BCG) vaccination. Results showed that in vitro MSU cause an enduring macrophage stimulation of the anti-my...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Taus, Francesco, Santucci, Marilina B., Greco, Emanuela, Morandi, Matteo, Palucci, Ivana, Mariotti, Sabrina, Poerio, Noemi, Nisini, Roberto, Delogu, Giovanni, Fraziano, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449037/
https://ncbi.nlm.nih.gov/pubmed/26023779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127279
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