Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy

We have developed a producer cell line that generates lentiviral vector particles of high titer. The vector encodes the Wiskott-Aldrich syndrome (WAS) protein. An insulator element has been added to the long terminal repeats of the integrated vector to limit proto-oncogene activation. The vector pro...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Wielgosz, Matthew M, Kim, Yoon-Sang, Carney, Gael G, Zhan, Jun, Reddivari, Muralidhar, Coop, Terry, Heath, Richard J, Brown, Scott A, Nienhuis, Arthur W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449020/
https://ncbi.nlm.nih.gov/pubmed/26052531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.63
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